The new crown vaccination work is being carried out nationwide. Because inactivated vaccines are extremely temperature-sensitive, the storage temperature of the entire cold chain transportation must be kept within the range of 2°C-8°C to ensure the stability and antigenicity of the vaccine. However, in actual operation, from vaccine production and delivery to vaccination, it needs to go through multiple links of circulation, transportation and storage. However, refrigerated drugs may have "cold chain failure" or "broken chain" due to poor temperature monitoring, which is a serious threat Drug quality and drug safety for the public.

How to collect and monitor temperature records during transportation and storage to ensure the quality of the vaccine, so as to ensure the visualization of the temperature throughout the cold chain logistics? Let's take a look at Fudan Microelectronics' solutions!

Equipped with Fudan Microelectronics MCU Cold Chain Data Logger

The cold chain data logger can collect the ambient temperature at a certain time interval and record the data. Before use, users can set the temperature threshold according to their needs, and automatically alarm when the threshold is exceeded; the recorder has a USB interface, plug the recorder into a PC to automatically generate a temperature record report in PDF format without installing any software.

Functional block diagram of cold chain temperature recorder Fudan Microelectronics FM33LC0xxU series products are evaluated by users as the most suitable MCU for cold chain data meters. This series of MCUs still maintain the strong advantages of ultra-low power consumption, while integrating LCD driver and USB2.0 FS Device interface, including on-chip crystal-less PHY and MAC controllers, supporting the implementation of USB MSC, HID, CDC and other device types.

In response to the application requirements of cold chain data recorders, the Fudan Microelectronics MCU team released a dedicated library for PDF Library, which provides a rich API interface for generating PDF files: supports PDF encryption and compression; supports 14 standard fonts; supports English and Chinese , Japanese, Cyrillic and other texts; support the display of pictures in formats such as .bmp, .jpg, .jp2; support font size and color settings; support solid lines, dashed lines, curves and matrix drawing; support line segment width, color settings and other functions.

Relying on the product's good stability and anti-interference, with the help of perfect underlying drivers and routines, and with high-quality technical support, Fudan Micro has been supplying batches to many leading cold chain data logger companies. In the future, in the cold chain logistics industry, more and more Fudan Micro MCUs will appear. The FM33LC0xxx series is a large family with rich peripheral resources and diverse packaging types, based on providing users with cost-effective ultra-low power solutions.

Fudan Microelectronics Dual Frequency Temperature Measurement RFID Tag

At present, fudan chip card products related to cold chain temperature measurement and monitoring on the market generally suffer from unstable performance, low sensitivity, and complicated detection systems, which may cause temperature monitoring to be interrupted and temperature inaccurate. Fudan Microelectronics Group has developed and designed the world's first dual-frequency three-interface temperature measurement RFID chip, which is used in global cold chain temperature monitoring.

This dual-frequency temperature measurement RFID chip has the following characteristics:

● It has a total of three interfaces, contact and non-contact interfaces. The contact interface adopts the I2C protocol. The high-frequency interface of the non-contact interface can choose ISO14443 or ISO15693 standards, which are in line with the NFC FORUM data specification, and support Android and Apple mobile phones to read temperature data ;

● UHF interface supports EPC Global C1G2 and ISO18000-6C standards;

● Built-in high-precision temperature sensor, which can complete real-time or timing environmental temperature measurement;

● The chip has a built-in high-precision RTC, which can perform more accurate timing wake-up operations;

● Built-in large-capacity EEPROM, which can be used to store long-term temperature data, and can also be used to record pressure or humidity data measured by external sensors.

This dual-frequency temperature measurement RFID chip realizes the long-distance, large-scale automatic collection of temperature data by the supervisor and the vaccine recipient, ensuring the accuracy and traceability of the corresponding time of the temperature point, and all data can be uploaded to the background for storage and analysis . In addition, the large-capacity and highly reliable memory, extremely low standby power consumption and battery operating voltage ensure long-term temperature data storage, which can meet the requirements of sea transportation. In addition to the main company's temperature monitoring, Fudan Microelectronics dual-frequency temperature measurement RFID chip card also has photosensitive properties, which is suitable for logistics monitoring of drugs that need to be stored in the dark.

Temperature measurement tags can also be applied to human body temperature monitoring, which can accurately record body temperature change data, and "cloud monitoring" of body temperature data through mobile phones. During the COVID-19 pandemic, this product was used in Wuhan Fangcai Hospital and many communities across the country. It records body temperature at a frequency of 1 minute per time. It can work continuously for 80 hours and achieve up to 4,800 temperature measurements, successfully solving patients. The difficulty of continuous temperature monitoring, and fully demonstrates the characteristics of continuous temperature measurement, accurate data, and long-term recording.

Sum up

Different from the general fresh cold chain, the threshold of the vaccine cold chain is relatively high, so it is listed as the top of the cold chain industry pyramid in terms of technical difficulty. With the popularity of the new crown vaccine, the demand for cold chain transportation at home and abroad will be huge. With its self-developed high-end technology and products, Fudan Microelectronics will continue to work with industry partners to realize the full temperature visualization of cold chain logistics, ensure the authenticity and integrity of data, and jointly build a more complete cold chain logistics distribution management system.